Structure analysis

Crystal structure of the IL-22/IL-22R1 complex

X-ray diffraction
1.9Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 17339.7 Å2
Buried surface area: 1707.02 Å2
Dissociation area: 853.51 Å2
Dissociation energy (ΔGdiss): -1.63 kcal/mol
Dissociation entropy (TΔSdiss): 11.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185421

Macromolecules

Chain: I
Length: 151 amino acids
Theoretical weight: 17.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9GZX6 (Residues: 29-179; Coverage: 100%)
Gene names: IL22, ILTIF, UNQ3099/PRO10096, ZCYTO18
Pfam: Interleukin 22 IL-10-related T-cell-derived-inducible factor
InterPro:
CATH: Growth Hormone; Chain: A;
SCOP: Interferons/interleukin-10 (IL-10)

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Chain: R
Length: 211 amino acids
Theoretical weight: 24.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N6P7 (Residues: 18-228; Coverage: 38%)
Gene names: IL22R, IL22RA1
Pfam: Tissue factor
InterPro:
CATH: Immunoglobulins

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