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Crystal structure of human haspin in complex with AMP

X-ray diffraction
1.85Å resolution
PDB entry 3dlz coloured by chain, front view.
PDB entry 3dlz coloured by chain, side view.
PDB entry 3dlz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase haspin
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Multimeric state: monomeric
Accessible surface area: 15167.26 Å2
Buried surface area: 1244.57 Å2
Dissociation area: 120.74 Å2
Dissociation energy (ΔGdiss): -1.97 kcal/mol
Dissociation entropy (TΔSdiss): -0.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186268
Monomeric assembly 1 of PDB entry 3dlz coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 3dlz coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 3dlz coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 95%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 1
Symmetry : None
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Serine/threonine-protein kinase haspin
Chain: A
Length: 357 amino acids
Theoretical weight: 40.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TF76 (Residues: 465-798; Coverage: 42%)
Gene names: GSG2, HASPIN
Pfam: Haspin like kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase haspin in PDB entry 3dlz, assembly 1, front view.
Serine/threonine-protein kinase haspin in PDB entry 3dlz, assembly 1, side view.
Serine/threonine-protein kinase haspin in PDB entry 3dlz, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q8TF76  
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