› › Structure analysis

Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-(2-nitroso-2-oxoethyl)biphenyl-4-sulfonamide

X-ray diffraction
1.1Å resolution
PDB entry 3f17 coloured by chain, front view.
PDB entry 3f17 coloured by chain, side view.
PDB entry 3f17 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Macrophage metalloelastase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 8142.93 Å2
Buried surface area: 177.75 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-544352

Macromolecules

Macrophage metalloelastase
Chain: A
Length: 158 amino acids
Theoretical weight: 17.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39900 (Residues: 106-263; Coverage: 35%)
Gene names: HME, MMP12
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
Macrophage metalloelastase in PDB entry 3f17, assembly 1, front view.
Macrophage metalloelastase in PDB entry 3f17, assembly 1, side view.
Macrophage metalloelastase in PDB entry 3f17, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links