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Structural Basis of PP2A and Sgo interaction

X-ray diffraction
2.7Å resolution
PDB entry 3fga coloured by chain, front view.
PDB entry 3fga coloured by chain, side view.
PDB entry 3fga coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 56112.15 Å2
Buried surface area: 11315.9 Å2
Dissociation area: 886.37 Å2
Dissociation energy (ΔGdiss): 2.21 kcal/mol
Dissociation entropy (TΔSdiss): 11.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159229

Macromolecules

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Chain: A
Length: 588 amino acids
Theoretical weight: 65.26 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q76MZ3 (Residues: 2-589; Coverage: 100%)
Gene name: Ppp2r1a
Pfam:
InterPro:
CATH: Leucine-rich Repeat Variant
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 3fga, assembly 1, front view.
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 3fga, assembly 1, side view.
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform in PDB entry 3fga, assembly 1, top view.
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Chain: B
Length: 403 amino acids
Theoretical weight: 47.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13362 (Residues: 34-436; Coverage: 77%)
Gene names: KIAA0044, PPP2R5C
Pfam: Protein phosphatase 2A regulatory B subunit (B56 family)
InterPro:
CATH: Leucine-rich Repeat Variant
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform in PDB entry 3fga, assembly 1, front view.
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform in PDB entry 3fga, assembly 1, side view.
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform in PDB entry 3fga, assembly 1, top view.
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Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Chain: C
Length: 309 amino acids
Theoretical weight: 35.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P67775 (Residues: 1-309; Coverage: 100%)
Gene name: PPP2CA
Pfam: Calcineurin-like phosphoesterase
InterPro:
CATH: Purple Acid Phosphatase; chain A, domain 2
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 3fga, assembly 1, front view.
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 3fga, assembly 1, side view.
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform in PDB entry 3fga, assembly 1, top view.
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Shugoshin 1
Chain: D
Length: 47 amino acids
Theoretical weight: 5.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5FBB7 (Residues: 51-96; Coverage: 8%)
Gene names: SGO1, SGOL1
Pfam: Shugoshin N-terminal coiled-coil region
InterPro: Shugoshin 1/2
CATH: Single helix bin
Shugoshin 1 in PDB entry 3fga, assembly 1, front view.
Shugoshin 1 in PDB entry 3fga, assembly 1, side view.
Shugoshin 1 in PDB entry 3fga, assembly 1, top view.
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MICROCYSTIN-LR
Chain: E
Length: 7 amino acids
Theoretical weight: 1.01 KDa
Source organism: Microcystis aeruginosa
Expression system: Not provided
MICROCYSTIN-LR in PDB entry 3fga, assembly 1, front view.
MICROCYSTIN-LR in PDB entry 3fga, assembly 1, side view.
MICROCYSTIN-LR in PDB entry 3fga, assembly 1, top view.
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