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Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4

X-ray diffraction
2Å resolution
PDB entry 3g0u coloured by chain, front view.
PDB entry 3g0u coloured by chain, side view.
PDB entry 3g0u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dihydroorotate dehydrogenase (quinone), mitochondrial
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Multimeric state: monomeric
Accessible surface area: 14413.94 Å2
Buried surface area: 1182.17 Å2
Dissociation area: 207.33 Å2
Dissociation energy (ΔGdiss): -2.5 kcal/mol
Dissociation entropy (TΔSdiss): 2.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-169672

Macromolecules

Dihydroorotate dehydrogenase (quinone), mitochondrial
Chain: A
Length: 367 amino acids
Theoretical weight: 39.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02127 (Residues: 29-395; Coverage: 93%)
Gene name: DHODH
Pfam: Dihydroorotate dehydrogenase
InterPro:
CATH: Aldolase class I
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 3g0u, assembly 1, front view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 3g0u, assembly 1, side view.
Dihydroorotate dehydrogenase (quinone), mitochondrial in PDB entry 3g0u, assembly 1, top view.
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