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Structure of the mycobacterium tuberculosis DUTPase D28N mutant

X-ray diffraction
1.8Å resolution
PDB entry 3h6d coloured by chain, front view.
PDB entry 3h6d coloured by chain, side view.
PDB entry 3h6d coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Assemblies composition:
homo trimer
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase
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Multimeric state: homo trimer
Accessible surface area: 17525.49 Å2
Buried surface area: 14444.18 Å2
Dissociation area: 6,316.09 Å2
Dissociation energy (ΔGdiss): 56.92 kcal/mol
Dissociation entropy (TΔSdiss): 26.29 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-161882
Assembly 2 (preferred)
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Assembly Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase
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Multimeric state: monomeric
Accessible surface area: 9745.57 Å2
Buried surface area: 901.07 Å2
Dissociation area: 79.96 Å2
Dissociation energy (ΔGdiss): -2.77 kcal/mol
Dissociation entropy (TΔSdiss): 1.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-161881

Macromolecules

Deoxyuridine 5'-triphosphate nucleotidohydrolase
Chain: A
Length: 174 amino acids
Theoretical weight: 17.99 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WNS5 (Residues: 1-154; Coverage: 100%)
Gene names: MTCY05A6.18c, Rv2697c, dut
Pfam: dUTPase
InterPro:
CATH: Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A
Deoxyuridine 5'-triphosphate nucleotidohydrolase in PDB entry 3h6d, assembly 2, front view.
Deoxyuridine 5'-triphosphate nucleotidohydrolase in PDB entry 3h6d, assembly 2, side view.
Deoxyuridine 5'-triphosphate nucleotidohydrolase in PDB entry 3h6d, assembly 2, top view.
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