PDB 3hha citation summary ‹ Protein Data Bank in Europe (PDBe)

Therapeutic strategies for COVID-19: progress and lessons learned. Li G, Hilgenfeld R, Whitley R, De Clercq E. Nat Rev Drug Discov 22 449-475 (2023)
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L. Dana D, Pathak SK. Molecules 25 E698 (2020)

Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Adams-Cioaba MA, Krupa JC, Xu C, Mort JS, Min J. Nat Commun 2 197 (2011)
Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form. Wong JJ, Paterson RG, Lamb RA, Jardetzky TS. Proc Natl Acad Sci U S A 113 1056-1061 (2016)
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. J Med Chem 65 2956-2970 (2022)
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L. Costanzi E, Kuzikov M, Esposito F, Albani S, Demitri N, Giabbai B, Camasta M, Tramontano E, Rossetti G, Zaliani A, Storici P. Int J Mol Sci 22 11779 (2021)
Evolutionary selection of enzymatically synthesized semiconductors from biomimetic mineralization vesicles. Bawazer LA, Izumi M, Kolodin D, Neilson JR, Schwenzer B, Morse DE. Proc Natl Acad Sci U S A 109 E1705-14 (2012)
Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. Avelar LA, Camilo CD, de Albuquerque S, Fernandes WB, Gonçalez C, Kenny PW, Leitão A, McKerrow JH, Montanari CA, Orozco EV, Ribeiro JF, Rocha JR, Rosini F, Saidel ME. PLoS Negl Trop Dis 9 e0003916 (2015)
Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L. Phan HAT, Giannakoulias SG, Barrett TM, Liu C, Petersson EJ. Chem Sci 12 10825-10835 (2021)
Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability. Zwicker JD, Diaz NA, Guerra AJ, Kirchhoff PD, Wen B, Sun D, Carruthers VB, Larsen SD. Bioorg Med Chem Lett 28 1972-1980 (2018)
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins. Tušar L, Loboda J, Impens F, Sosnowski P, Van Quickelberghe E, Vidmar R, Demol H, Sedeyn K, Saelens X, Vizovišek M, Mihelič M, Fonović M, Horvat J, Kosec G, Turk B, Gevaert K, Turk D. Commun Biol 6 450 (2023)
Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads. Karges J, Cohen SM. J Med Chem 66 3088-3105 (2023)
Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells. Cecarini V, Selmi S, Cuccioloni M, Gong C, Bonfili L, Zheng Y, Cortese M, Angeletti M, Kilani S, Eleuteri AM. Molecules 27 7591 (2022)
In Silico Analysis Reveals the Inhibitory Potential of Madecassic Acid against Entry Factors of SARS-CoV-2. Ganguly A, Mandi M, Dutta A, Rajak P. ACS Appl Bio Mater 6 652-662 (2023)
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. Bonatto V, Batista PHJ, Cianni L, De Vita D, Silva DG, Cedron R, Tezuka DY, de Albuquerque S, Moraes CB, Franco CH, Lameira J, Leitão A, Montanari CA. RSC Med Chem 11 1275-1284 (2020)
Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle Zulkipli M, Mahbub N, Fatima A, Wan-Lin SL, Khoo TJ, Mahboob T, Rajagopal M, Samudi C, Kathirvalu G, Abdullah NH, Pinho AR, Oliveira SMR, Pereira ML, Rahmatullah M, Hasan A, Paul AK, Butler MS, Nawaz M, Wilairatana P, Nissapatorn V, Wiart C. Plants (Basel) 11 1388 (2022)
Ginsenosides Rg1 and Rg2 Activate Autophagy and Attenuate Oxidative Stress in Neuroblastoma Cells Overexpressing Aβ(1-42). Liu Z, Cecarini V, Cuccioloni M, Bonfili L, Gong C, Angeletti M, Eleuteri AM. Antioxidants (Basel) 13 310 (2024)
Targeting Cathepsin L in Cancer Management: Leveraging Machine Learning, Structure-Based Virtual Screening, and Molecular Dynamics Studies. Almalki AA, Shafie A, Hazazi A, Banjer HJ, Bakhuraysah MM, Almaghrabi SA, Alsaiari AA, Alsaeedi FA, Ashour AA, Alharthi A, Alharthi NS, Anjum F. Int J Mol Sci 24 17208 (2023)

Cysteine cathepsins: from structure, function and regulation to new frontiers. Turk V, Stoka V, Vasiljeva O, Renko M, Sun T, Turk B, Turk D. Biochim Biophys Acta 1824 68-88 (2012)
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Siklos M, BenAissa M, Thatcher GR. Acta Pharm Sin B 5 506-519 (2015)
Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors. Kemp M. Prog Med Chem 55 149-192 (2016)
Cathepsin S inhibitors: 2004-2010. Lee-Dutra A, Wiener DK, Sun S. Expert Opin Ther Pat 21 311-337 (2011)
Cathepsin L in metastatic bone disease: therapeutic implications. Leto G, Sepporta MV, Crescimanno M, Flandina C, Tumminello FM. Biol Chem 391 655-664 (2010)
Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers. Qian D, He L, Zhang Q, Li W, Tang D, Wu C, Yang F, Li K, Zhang H. Curr Oncol 29 5963-5987 (2022)
Nitriles: an attractive approach to the development of covalent inhibitors. Bonatto V, Lameiro RF, Rocho FR, Lameira J, Leitão A, Montanari CA. RSC Med Chem 14 201-217 (2023)

Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. Sun W, Wu X, Gao H, Yu J, Zhao W, Lu JJ, Wang J, Du G, Chen X. Free Radic Biol Med 108 433-444 (2017)
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, Arispe WM, Macdonough MT, Strecker TE, Chen SE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG. Bioorg Med Chem Lett 20 1415-1419 (2010)
Experimental study and computational modelling of cruzain cysteine protease inhibition by dipeptidyl nitriles. Dos Santos AM, Cianni L, De Vita D, Rosini F, Leitão A, Laughton CA, Lameira J, Montanari CA. Phys Chem Chem Phys 20 24317-24328 (2018)
Design of selective Cathepsin inhibitors. Bethel PA, Gerhardt S, Jones EV, Kenny PW, Karoutchi GI, Morley AD, Oldham K, Rankine N, Augustin M, Krapp S, Simader H, Steinbacher S. Bioorg Med Chem Lett 19 4622-4625 (2009)
Letter Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L. Sosnowski P, Turk D. FEBS Lett 590 1253-1261 (2016)
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Parker EN, Song J, Kishore Kumar GD, Odutola SO, Chavarria GE, Charlton-Sevcik AK, Strecker TE, Barnes AL, Sudhan DR, Wittenborn TR, Siemann DW, Horsman MR, Chaplin DJ, Trawick ML, Pinney KG. Bioorg Med Chem 23 6974-6992 (2015)
Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors? Torkar A, Lenarčič B, Lah T, Dive V, Devel L. Bioorg Med Chem Lett 23 2968-2973 (2013)
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks. Song J, Jones LM, Chavarria GE, Charlton-Sevcik AK, Jantz A, Johansen A, Bayeh L, Soeung V, Snyder LK, Lade SD, Chaplin DJ, Trawick ML, Pinney KG. Bioorg Med Chem Lett 23 2801-2807 (2013)
2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H. Singh M, Raghav N. Bioorg Chem 59 12-22 (2015)
Mapping the S1 and S1' subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents. Cianni L, Lemke C, Gilberg E, Feldmann C, Rosini F, Rocho FDR, Ribeiro JFR, Tezuka DY, Lopes CD, de Albuquerque S, Bajorath J, Laufer S, Leitão A, Gütschow M, Montanari CA. PLoS Negl Trop Dis 14 e0007755 (2020)
Self Organizing Map-Based Classification of Cathepsin k and S Inhibitors with Different Selectivity Profiles Using Different Structural Molecular Fingerprints: Design and Application for Discovery of Novel Hits. Ihmaid SK, Ahmed HE, Zayed MF, Abadleh MM. Molecules 21 175 (2016)
A mechanistic study on the inhibition of α-chymotrypsin by a macrocyclic peptidomimetic aldehyde. Zhang X, Bruning JB, George JH, Abell AD. Org Biomol Chem 14 6970-6978 (2016)

Protein Data Bank in Europe

Dipeptidyl nitrile inhibitors of Cathepsin L.

Abstract

Reviews - 3hha mentioned but not cited (2)

Articles - 3hha mentioned but not cited (16)

Reviews citing this publication (7)

Articles citing this publication (12)

Quick links

3hha › Citations

Dipeptidyl nitrile inhibitors of Cathepsin L.

Abstract

Reviews - 3hha mentioned but not cited (2)

Articles - 3hha mentioned but not cited (16)

Reviews citing this publication (7)

Articles citing this publication (12)

Quick links