Structure analysis

Crystal structure of cathepsin L in complex with AZ12878478

X-ray diffraction
1.27Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 9785.54 Å2
Buried surface area: 628.38 Å2
Dissociation area: 226.26 Å2
Dissociation energy (ΔGdiss): -8.5 kcal/mol
Dissociation entropy (TΔSdiss): 3.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718
Assembly 2
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 9683.72 Å2
Buried surface area: 324.28 Å2
Dissociation area: 162.14 Å2
Dissociation energy (ΔGdiss): -5.74 kcal/mol
Dissociation entropy (TΔSdiss): 2.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718
Assembly 3
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 9457.8 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718
Assembly 4
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 10092.38 Å2
Buried surface area: 207.59 Å2
Dissociation area: 103.79 Å2
Dissociation energy (ΔGdiss): 1.06 kcal/mol
Dissociation entropy (TΔSdiss): 0.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718

Macromolecules

Chains: A, B, C, D
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07711 (Residues: 114-333; Coverage: 70%)
Gene names: CTSL, CTSL1
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases

Search similar proteins