Structure analysis

Structure of the Human Fatty Acid Synthase KS-MAT Didomain as a Framework for Inhibitor Design.

X-ray diffraction
2.15Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 58752.23 Å2
Buried surface area: 5513.3 Å2
Dissociation area: 2,694.21 Å2
Dissociation energy (ΔGdiss): 31.88 kcal/mol
Dissociation entropy (TΔSdiss): 16.32 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155926
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 58867.07 Å2
Buried surface area: 5531.32 Å2
Dissociation area: 2,704 Å2
Dissociation energy (ΔGdiss): 30.87 kcal/mol
Dissociation entropy (TΔSdiss): 16.32 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-155926

Macromolecules

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