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Crystal structure of Ricin A-chain in complex with the cyclic tetranucleotide inhibitor, a transition state analogue

Source organism: Ricinus communis
Biochemical function: rRNA N-glycosylase activity
Biological process: negative regulation of translation
Cellular component: not assigned

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EC 3.2.2.22: rRNA N-glycosylase

Reaction catalysed:
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
Systematic name:
rRNA N-glycohydrolase
Alternative Name(s):
  • Gelonin
  • Mirabilis antiviral protein
  • Momorcochin-S
  • Nigrin b
  • RNA N-glycosidase
  • Ribosomal ribonucleate N-glycosidase
  • Ricin
  • Saporins
  • rRNA N-glycosidase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00161
Domain description: Ribosome inactivating protein
Occurring in:
  1. Ricin A chain
The deposited structure of PDB entry 3hio contains 1 copy of Pfam domain PF00161 (Ribosome inactivating protein) in Ricin A chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR017989
Domain description: Ribosome-inactivating protein type 1/2
Occurring in:
  1. Ricin A chain
IPR001574
Domain description: Ribosome-inactivating protein
Occurring in:
  1. Ricin A chain
IPR016139
Domain description: Ribosome-inactivating protein, subdomain 2
Occurring in:
  1. Ricin A chain
IPR017988
Domain description: Ribosome-inactivating protein conserved site
Occurring in:
  1. Ricin A chain
IPR036041
Domain description: Ribosome-inactivating protein superfamily
Occurring in:
  1. Ricin A chain
IPR016138
Domain description: Ribosome-inactivating protein, subdomain 1
Occurring in:
  1. Ricin A chain

Structure domains

CATH CATH domains
4.10.470.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Ricin (A Subunit), domain 2
Homology: Ricin (A Subunit), domain 2
Occurring in:
  1. Ricin A chain
The deposited structure of PDB entry 3hio contains 1 copy of CATH domain 4.10.470.10 (Ricin (A Subunit), domain 2) in Ricin A chain. Showing 1 copy in chain A.
3.40.420.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Ricin (A subunit); domain 1
Homology: Ricin (A subunit), domain 1
Occurring in:
  1. Ricin A chain
The deposited structure of PDB entry 3hio contains 1 copy of CATH domain 3.40.420.10 (Ricin (A subunit); domain 1) in Ricin A chain. Showing 1 copy in chain A.

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