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Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK

X-ray diffraction
2.1Å resolution
PDB entry 3hkl coloured by chain, front view.
PDB entry 3hkl coloured by chain, side view.
PDB entry 3hkl coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Muscle, skeletal receptor tyrosine protein kinase
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Multimeric state: homo dimer
Accessible surface area: 14898.72 Å2
Buried surface area: 3009.05 Å2
Dissociation area: 952.56 Å2
Dissociation energy (ΔGdiss): 3.14 kcal/mol
Dissociation entropy (TΔSdiss): 11.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178971
Homo dimeric assembly 1 of PDB entry 3hkl coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 3hkl coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 3hkl coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 89%
No. subunits : 2
Symmetry : NS
More details
3DComplex & QSbio predictionx
No. subunits : Unclear
Symmetry : Unclear
Evidence : This biological assembly agrees with the prediction of PISA but not of EPPIC

Macromolecules

Muscle, skeletal receptor tyrosine protein kinase
Chains: A, B
Length: 197 amino acids
Theoretical weight: 21.89 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62838 (Residues: 313-494; Coverage: 22%)
Gene name: Musk
Pfam: Fz domain
InterPro:
CATH: Frizzled cysteine-rich domain
Muscle, skeletal receptor tyrosine protein kinase in PDB entry 3hkl, assembly 1, front view.
Muscle, skeletal receptor tyrosine protein kinase in PDB entry 3hkl, assembly 1, side view.
Muscle, skeletal receptor tyrosine protein kinase in PDB entry 3hkl, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q62838  
119720406080100120140160180
 
50100150
UniProt
Q62838
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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