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Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD

X-ray diffraction
2.64Å resolution
PDB entry 3hph coloured by chain, front view.
PDB entry 3hph coloured by chain, side view.
PDB entry 3hph coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: PC4 and SFRS1-interacting protein and Integrase
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Multimeric state: hetero octamer
Accessible surface area: 49550.06 Å2
Buried surface area: 16962.71 Å2
Dissociation area: 2,978.13 Å2
Dissociation energy (ΔGdiss): -5.35 kcal/mol
Dissociation entropy (TΔSdiss): 45.78 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-522053

Macromolecules

Integrase
Chains: A, B, C, D
Length: 219 amino acids
Theoretical weight: 25.09 KDa
Source organism: Visna/maedi virus EV1 KV1772
Expression system: Escherichia coli
UniProt:
  • Canonical: P35956 (Residues: 1228-1444; Coverage: 14%)
Gene name: pol
Pfam:
InterPro:
CATH:
Integrase in PDB entry 3hph, assembly 1, front view.
Integrase in PDB entry 3hph, assembly 1, side view.
Integrase in PDB entry 3hph, assembly 1, top view.
Molecule details ›

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PC4 and SFRS1-interacting protein
Chains: E, F, G, H
Length: 94 amino acids
Theoretical weight: 10.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75475 (Residues: 348-435; Coverage: 17%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Pfam: Lens epithelium-derived growth factor (LEDGF)
InterPro:
CATH: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
PC4 and SFRS1-interacting protein in PDB entry 3hph, assembly 1, front view.
PC4 and SFRS1-interacting protein in PDB entry 3hph, assembly 1, side view.
PC4 and SFRS1-interacting protein in PDB entry 3hph, assembly 1, top view.
Molecule details ›

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