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Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding

X-ray diffraction
2.694Å resolution
PDB entry 3hxq coloured by chain, front view.
PDB entry 3hxq coloured by chain, side view.
PDB entry 3hxq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: von Willebrand factor and DNA
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Multimeric state: hetero dimer
Accessible surface area: 15239.09 Å2
Buried surface area: 2141.52 Å2
Dissociation area: 1,070.76 Å2
Dissociation energy (ΔGdiss): 1.21 kcal/mol
Dissociation entropy (TΔSdiss): 11.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116385

Macromolecules

von Willebrand factor
Chain: A
Length: 209 amino acids
Theoretical weight: 23.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04275 (Residues: 1260-1468; Coverage: 8%)
Gene names: F8VWF, VWF
Pfam: von Willebrand factor type A domain
InterPro:
CATH: von Willebrand factor, type A domain
von Willebrand factor in PDB entry 3hxq, assembly 1, front view.
von Willebrand factor in PDB entry 3hxq, assembly 1, side view.
von Willebrand factor in PDB entry 3hxq, assembly 1, top view.
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DNA chain B
Name: Aptamer ARC1172
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 42 nucleotides
Theoretical weight: 12.88 KDa
Aptamer ARC1172 in PDB entry 3hxq, assembly 1, front view.
Aptamer ARC1172 in PDB entry 3hxq, assembly 1, side view.
Aptamer ARC1172 in PDB entry 3hxq, assembly 1, top view.
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