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Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: cell differentiation
Cellular component: membrane

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00066
Domain description: LNR domain
Occurring in:
  1. Neurogenic locus notch homolog protein 1
The deposited structure of PDB entry 3i08 contains 6 copies of Pfam domain PF00066 (LNR domain) in Neurogenic locus notch homolog protein 1. Showing 3 copies in chain A.

PF07684
Domain description: NOTCH protein
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3i08 contains 2 copies of Pfam domain PF07684 (NOTCH protein) in Notch 1 extracellular truncation. Showing 1 copy in chain B.

PF06816
Domain description: NOTCH protein
Occurring in:
  1. Neurogenic locus notch homolog protein 1
The deposited structure of PDB entry 3i08 contains 2 copies of Pfam domain PF06816 (NOTCH protein) in Neurogenic locus notch homolog protein 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000800
Domain description: Notch domain
Occurring in:
  1. Neurogenic locus notch homolog protein 1
IPR035993
Domain description: Notch-like domain superfamily
Occurring in:
  1. Neurogenic locus notch homolog protein 1
IPR011656
Domain description: Notch, NODP domain
Occurring in:
  1. Notch 1 extracellular truncation
IPR010660
Domain description: Notch, NOD domain
Occurring in:
  1. Neurogenic locus notch homolog protein 1

Structure domains

CATH CATH domains
4.10.470.20
Class: Few Secondary Structures
Architecture: Irregular
Topology: Ricin (A Subunit), domain 2
Homology: Ricin (A Subunit), domain 2
Occurring in:
  1. Neurogenic locus notch homolog protein 1
The deposited structure of PDB entry 3i08 contains 4 copies of CATH domain 4.10.470.20 (Ricin (A Subunit), domain 2) in Neurogenic locus notch homolog protein 1. Showing 2 copies in chain A.
6.10.250.470
Class: Special
Architecture: Helix non-globular
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Notch 1 extracellular truncation
The deposited structure of PDB entry 3i08 contains 2 copies of CATH domain 6.10.250.470 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Notch 1 extracellular truncation. Showing 1 copy in chain B.

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