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Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues)

X-ray diffraction
1.65Å resolution
PDB entry 3iux coloured by chain, front view.
PDB entry 3iux coloured by chain, side view.
PDB entry 3iux coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: E3 ubiquitin-protein ligase Mdm2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6355.83 Å2
Buried surface area: 1953.92 Å2
Dissociation area: 580.7 Å2
Dissociation energy (ΔGdiss): 4.27 kcal/mol
Dissociation entropy (TΔSdiss): 8.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-163673
Assembly 2
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Assembly Name: E3 ubiquitin-protein ligase Mdm2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6223.19 Å2
Buried surface area: 1550.22 Å2
Dissociation area: 571.75 Å2
Dissociation energy (ΔGdiss): 5.82 kcal/mol
Dissociation entropy (TΔSdiss): 8.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-163673

Macromolecules

E3 ubiquitin-protein ligase Mdm2
Chains: A, C
Length: 85 amino acids
Theoretical weight: 10.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q00987 (Residues: 25-109; Coverage: 17%)
Gene name: MDM2
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
E3 ubiquitin-protein ligase Mdm2 in PDB entry 3iux, assembly 1, front view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 3iux, assembly 1, side view.
E3 ubiquitin-protein ligase Mdm2 in PDB entry 3iux, assembly 1, top view.
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miniature protein inhibitor
Chains: B, D
Length: 18 amino acids
Theoretical weight: 2.22 KDa
Source organism: Homo sapiens
Expression system: Not provided
miniature protein inhibitor in PDB entry 3iux, assembly 1, front view.
miniature protein inhibitor in PDB entry 3iux, assembly 1, side view.
miniature protein inhibitor in PDB entry 3iux, assembly 1, top view.
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