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Cryo-EM structure of GTPgammaS-microtubule co-polymerized with EB3 (merged dataset with and without kinesin bound)

Source organisms:
Biochemical function: metal ion binding
Biological process: microtubule-based process
Cellular component: microtubule

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF03953
Domain description: Tubulin C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
The deposited structure of PDB entry 3jak contains 6 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin alpha-1B chain. Showing 1 copy in chain J [auth A].
The deposited structure of PDB entry 3jak contains 6 copies of Pfam domain PF03953 (Tubulin C-terminal domain) in Tubulin beta chain. Showing 1 copy in chain K [auth B].

PF00091
Domain description: Tubulin/FtsZ family, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
The deposited structure of PDB entry 3jak contains 6 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin alpha-1B chain. Showing 1 copy in chain J [auth A].
The deposited structure of PDB entry 3jak contains 6 copies of Pfam domain PF00091 (Tubulin/FtsZ family, GTPase domain) in Tubulin beta chain. Showing 1 copy in chain K [auth B].

PF00307
Domain description: Calponin homology (CH) domain
Occurring in:
  1. Microtubule-associated protein RP/EB family member 3
The deposited structure of PDB entry 3jak contains 2 copies of Pfam domain PF00307 (Calponin homology (CH) domain) in Microtubule-associated protein RP/EB family member 3. Showing 1 copy in chain L [auth M].

InterPro InterPro annotations
IPR000217
Domain description: Tubulin
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR002453
Domain description: Beta tubulin
Occurring in:
  1. Tubulin beta chain
IPR002452
Domain description: Alpha tubulin
Occurring in:
  1. Tubulin alpha-1B chain
IPR018316
Domain description: Tubulin/FtsZ, 2-layer sandwich domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR003008
Domain description: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR036525
Domain description: Tubulin/FtsZ, GTPase domain superfamily
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR023123
Domain description: Tubulin, C-terminal
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR037103
Domain description: Tubulin/FtsZ-like, C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR008280
Domain description: Tubulin/FtsZ, C-terminal
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR017975
Domain description: Tubulin, conserved site
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
IPR013838
Domain description: Beta tubulin, autoregulation binding site
Occurring in:
  1. Tubulin beta chain
IPR001715
Domain description: Calponin homology domain
Occurring in:
  1. Microtubule-associated protein RP/EB family member 3
IPR036872
Domain description: CH domain superfamily
Occurring in:
  1. Microtubule-associated protein RP/EB family member 3
IPR027328
Domain description: Microtubule-associated protein RP/EB
Occurring in:
  1. Microtubule-associated protein RP/EB family member 3

Structure domains

CATH CATH domains
1.10.287.600
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix hairpin bin
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
The deposited structure of PDB entry 3jak contains 6 copies of CATH domain 1.10.287.600 (Helix Hairpins) in Tubulin alpha-1B chain. Showing 1 copy in chain J [auth A].
The deposited structure of PDB entry 3jak contains 6 copies of CATH domain 1.10.287.600 (Helix Hairpins) in Tubulin beta chain. Showing 1 copy in chain K [auth B].
3.30.1330.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: 60s Ribosomal Protein L30; Chain: A;
Homology: Tubulin/FtsZ, C-terminal domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
The deposited structure of PDB entry 3jak contains 6 copies of CATH domain 3.30.1330.20 (60s Ribosomal Protein L30; Chain: A;) in Tubulin alpha-1B chain. Showing 1 copy in chain J [auth A].
The deposited structure of PDB entry 3jak contains 6 copies of CATH domain 3.30.1330.20 (60s Ribosomal Protein L30; Chain: A;) in Tubulin beta chain. Showing 1 copy in chain K [auth B].
3.40.50.1440
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Tubulin/FtsZ, GTPase domain
Occurring in:
  1. Tubulin alpha-1B chain
  2. Tubulin beta chain
The deposited structure of PDB entry 3jak contains 6 copies of CATH domain 3.40.50.1440 (Rossmann fold) in Tubulin alpha-1B chain. Showing 1 copy in chain J [auth A].
The deposited structure of PDB entry 3jak contains 6 copies of CATH domain 3.40.50.1440 (Rossmann fold) in Tubulin beta chain. Showing 1 copy in chain K [auth B].
1.10.418.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Actin-binding Protein, T-fimbrin; domain 1
Homology: Calponin-like domain
Occurring in:
  1. Microtubule-associated protein RP/EB family member 3
The deposited structure of PDB entry 3jak contains 2 copies of CATH domain 1.10.418.10 (Actin-binding Protein, T-fimbrin; domain 1) in Microtubule-associated protein RP/EB family member 3. Showing 1 copy in chain L [auth M].

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