Structure analysis

Crystal structure of human thrombin mutant N143P in E* form

X-ray diffraction
2.4Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 12610.28 Å2
Buried surface area: 3701.06 Å2
Dissociation area: 1,294.23 Å2
Dissociation energy (ΔGdiss): 9.36 kcal/mol
Dissociation entropy (TΔSdiss): 9.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133055
Complex Portal ID: CPX-6222

Macromolecules

Chain: A
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:

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Chain: B
Length: 259 amino acids
Theoretical weight: 29.76 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases

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