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HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol

X-ray diffraction
2.1Å resolution
PDB entry 3k99 coloured by chain, front view.
PDB entry 3k99 coloured by chain, side view.
PDB entry 3k99 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric
Accessible surface area: 11437.22 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139817
Assembly 2
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric
Accessible surface area: 10999.1 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139817
Assembly 3
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric
Accessible surface area: 10919.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139817
Assembly 4
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: monomeric
Accessible surface area: 11345.96 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139817
Assembly 5
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Assembly Name: Heat shock protein HSP 90-alpha
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Multimeric state: homo tetramer
Accessible surface area: 38864.75 Å2
Buried surface area: 5835.14 Å2
Dissociation area: 812.94 Å2
Dissociation energy (ΔGdiss): 0.53 kcal/mol
Dissociation entropy (TΔSdiss): 13.55 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-139827

Macromolecules

Heat shock protein HSP 90-alpha
Chains: A, B, C, D
Length: 232 amino acids
Theoretical weight: 26.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 8-225; Coverage: 30%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Pfam: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
InterPro:
CATH: Histidine kinase-like ATPase, C-terminal domain
Heat shock protein HSP 90-alpha in PDB entry 3k99, assembly 1, front view.
Heat shock protein HSP 90-alpha in PDB entry 3k99, assembly 1, side view.
Heat shock protein HSP 90-alpha in PDB entry 3k99, assembly 1, top view.
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