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Crystal Structure of a Rex-family transcriptional regulatory protein from Streptococcus agalactiae complexed with NAD+

Source organism: Streptococcus agalactiae serogroup III
Biochemical function: DNA-binding transcription factor activity
Biological process: response to redox state
Cellular component: cytoplasm

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02629
Domain description: CoA binding domain
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
The deposited structure of PDB entry 3keo contains 2 copies of Pfam domain PF02629 (CoA binding domain) in Redox-sensing transcriptional repressor Rex. Showing 1 copy in chain B.

PF06971
Domain description: Putative DNA-binding protein N-terminus
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
The deposited structure of PDB entry 3keo contains 2 copies of Pfam domain PF06971 (Putative DNA-binding protein N-terminus) in Redox-sensing transcriptional repressor Rex. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003781
Domain description: CoA-binding
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
IPR022876
Domain description: Redox-sensing transcriptional repressor Rex
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
IPR009718
Domain description: Rex DNA-binding, C-terminal domain
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Redox-sensing transcriptional repressor Rex

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
The deposited structure of PDB entry 3keo contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in Redox-sensing transcriptional repressor Rex. Showing 1 copy in chain B.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Redox-sensing transcriptional repressor Rex
The deposited structure of PDB entry 3keo contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Redox-sensing transcriptional repressor Rex. Showing 1 copy in chain B.

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