› 3kr3

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208412 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Insulin-like growth factor 2 Chain: D
Molecule details ›
Chain: D
Length: 67 amino acids
Theoretical weight: 7.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
antibody-Fab (heavy chain) Chain: H
Molecule details ›
Chain: H
Length: 251 amino acids
Theoretical weight: 26.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
antibody-Fab (light chain) Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 50.667Å b: 106.921Å c: 110.657Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.251
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation.
Girnita et al. (2014)
7 more

4 mentions without citation

Human germline antibody gene segments encode polyspecific antibodies.
Willis et al. (2013)
3 more