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Crystal structure of IGF-II antibody complex

X-ray diffraction
2.2Å resolution
PDB entry 3kr3 coloured by chain, front view.
PDB entry 3kr3 coloured by chain, side view.
PDB entry 3kr3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin-like growth factor 2 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 21626.25 Å2
Buried surface area: 6010.68 Å2
Dissociation area: 1,018.55 Å2
Dissociation energy (ΔGdiss): 4.43 kcal/mol
Dissociation entropy (TΔSdiss): 10.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-208412

Macromolecules

Insulin-like growth factor 2
Chain: D
Length: 67 amino acids
Theoretical weight: 7.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01344 (Residues: 25-91; Coverage: 43%)
Gene names: IGF-2, IGF2, PP1446
Pfam: Insulin/IGF/Relaxin family
InterPro:
CATH: Insulin-like
Insulin-like growth factor II in PDB entry 3kr3, assembly 1, front view.
Insulin-like growth factor II in PDB entry 3kr3, assembly 1, side view.
Insulin-like growth factor II in PDB entry 3kr3, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01344  
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antibody-Fab (heavy chain)
Chain: H
Length: 251 amino acids
Theoretical weight: 26.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
antibody-Fab (heavy chain) in PDB entry 3kr3, assembly 1, front view.
antibody-Fab (heavy chain) in PDB entry 3kr3, assembly 1, side view.
antibody-Fab (heavy chain) in PDB entry 3kr3, assembly 1, top view.
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antibody-Fab (light chain)
Chain: L
Length: 215 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
InterPro:
CATH: Immunoglobulins
antibody-Fab (light chain) in PDB entry 3kr3, assembly 1, front view.
antibody-Fab (light chain) in PDB entry 3kr3, assembly 1, side view.
antibody-Fab (light chain) in PDB entry 3kr3, assembly 1, top view.
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