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Structural basis of ataxin-2 recognition by poly(A)-binding protein

X-ray diffraction
1.7Å resolution
PDB entry 3ktr coloured by chain, front view.
PDB entry 3ktr coloured by chain, side view.
PDB entry 3ktr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Polyadenylate-binding protein 1 and Ataxin-2
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Multimeric state: hetero dimer
Accessible surface area: 6098.79 Å2
Buried surface area: 1904.92 Å2
Dissociation area: 743.97 Å2
Dissociation energy (ΔGdiss): 5.67 kcal/mol
Dissociation entropy (TΔSdiss): 8.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145998

Macromolecules

Polyadenylate-binding protein 1
Chain: A
Length: 88 amino acids
Theoretical weight: 9.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11940 (Residues: 544-626; Coverage: 13%)
Gene names: PAB1, PABP, PABP1, PABPC1, PABPC2
Pfam: Poly-adenylate binding protein, unique domain
InterPro:
CATH: c-terminal domain of poly(a) binding protein
Polyadenylate-binding protein 1 in PDB entry 3ktr, assembly 1, front view.
Polyadenylate-binding protein 1 in PDB entry 3ktr, assembly 1, side view.
Polyadenylate-binding protein 1 in PDB entry 3ktr, assembly 1, top view.
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Ataxin-2
Chain: B
Length: 17 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q99700 (Residues: 912-928; Coverage: 1%)
Gene names: ATX2, ATXN2, SCA2, TNRC13
Pfam: Ataxin-2 C-terminal region
InterPro: PAM2 motif
Ataxin-2 in PDB entry 3ktr, assembly 1, front view.
Ataxin-2 in PDB entry 3ktr, assembly 1, side view.
Ataxin-2 in PDB entry 3ktr, assembly 1, top view.
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