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Crystal structure of a H2N2 influenza virus hemagglutinin, 226L/228G

X-ray diffraction
1.75Å resolution
PDB entry 3ku6 coloured by chain, front view.
PDB entry 3ku6 coloured by chain, side view.
PDB entry 3ku6 coloured by chain, top view.
Source organism: Influenza A virus (A/Japan/305/1957(H2N2))
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hemagglutinin HA2 chain
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Multimeric state: hetero hexamer
Accessible surface area: 60900.88 Å2
Buried surface area: 31313.08 Å2
Dissociation area: 6,601.03 Å2
Dissociation energy (ΔGdiss): 63.81 kcal/mol
Dissociation entropy (TΔSdiss): 32.18 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-111765

Macromolecules

Hemagglutinin
Chain: A
Length: 327 amino acids
Theoretical weight: 36.49 KDa
Source organism: Influenza A virus (A/Japan/305/1957(H2N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C7S226 (Residues: 15-340; Coverage: 58%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH:
Hemagglutinin in PDB entry 3ku6, assembly 1, front view.
Hemagglutinin in PDB entry 3ku6, assembly 1, side view.
Hemagglutinin in PDB entry 3ku6, assembly 1, top view.
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Hemagglutinin HA2 chain
Chain: B
Length: 174 amino acids
Theoretical weight: 20.14 KDa
Source organism: Influenza A virus (A/Japan/305/1957(H2N2))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C7S226 (Residues: 341-514; Coverage: 31%)
Gene name: HA
Pfam: Haemagglutinin
InterPro:
CATH: Hemagglutinin Ectodomain; Chain B
Hemagglutinin HA2 chain in PDB entry 3ku6, assembly 1, front view.
Hemagglutinin HA2 chain in PDB entry 3ku6, assembly 1, side view.
Hemagglutinin HA2 chain in PDB entry 3ku6, assembly 1, top view.
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