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Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA

X-ray diffraction
1.868Å resolution
PDB entry 3l2c coloured by chain, front view.
PDB entry 3l2c coloured by chain, side view.
PDB entry 3l2c coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Forkhead box protein O4 and DNA
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Multimeric state: hetero trimer
Accessible surface area: 8663.37 Å2
Buried surface area: 3049.45 Å2
Dissociation area: 931.06 Å2
Dissociation energy (ΔGdiss): 18.87 kcal/mol
Dissociation entropy (TΔSdiss): 10.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116514

Macromolecules

Forkhead box protein O4
Chain: A
Length: 110 amino acids
Theoretical weight: 12.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P98177 (Residues: 86-187; Coverage: 20%)
Gene names: AFX, AFX1, FOXO4, MLLT7
Pfam: Forkhead domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Forkhead box protein O4 in PDB entry 3l2c, assembly 1, front view.
Forkhead box protein O4 in PDB entry 3l2c, assembly 1, side view.
Forkhead box protein O4 in PDB entry 3l2c, assembly 1, top view.
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DNA chain B
Name: FOXO consensus binding sequence, plus strand
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 13 nucleotides
Theoretical weight: 3.94 KDa
FOXO consensus binding sequence, plus strand in PDB entry 3l2c, assembly 1, front view.
FOXO consensus binding sequence, plus strand in PDB entry 3l2c, assembly 1, side view.
FOXO consensus binding sequence, plus strand in PDB entry 3l2c, assembly 1, top view.
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DNA chain C
Name: FOXO consensus binding sequence, minus strand
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 13 nucleotides
Theoretical weight: 4 KDa
FOXO consensus binding sequence, minus strand in PDB entry 3l2c, assembly 1, front view.
FOXO consensus binding sequence, minus strand in PDB entry 3l2c, assembly 1, side view.
FOXO consensus binding sequence, minus strand in PDB entry 3l2c, assembly 1, top view.
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