› › Structure analysis

Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex

X-ray diffraction
2.1Å resolution
PDB entry 3l9j coloured by chain, front view.
PDB entry 3l9j coloured by chain, side view.
PDB entry 3l9j coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Tetranectin and Tumor necrosis factor, soluble form
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 13764.58 Å2
Buried surface area: 1791.96 Å2
Dissociation area: 844.97 Å2
Dissociation energy (ΔGdiss): -4.61 kcal/mol
Dissociation entropy (TΔSdiss): 11.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134275

Macromolecules

Tetranectin
Chain: C
Length: 134 amino acids
Theoretical weight: 15.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05452 (Residues: 67-201; Coverage: 74%)
Gene names: CLEC3B, TNA
Pfam: Lectin C-type domain
InterPro:
CATH: Mannose-Binding Protein A, subunit A
Tetranectin in PDB entry 3l9j, assembly 1, front view.
Tetranectin in PDB entry 3l9j, assembly 1, side view.
Tetranectin in PDB entry 3l9j, assembly 1, top view.
Molecule details ›

Search similar proteins

Tumor necrosis factor, soluble form
Chain: T
Length: 149 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01375 (Residues: 85-233; Coverage: 64%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls
Tumor necrosis factor, soluble form in PDB entry 3l9j, assembly 1, front view.
Tumor necrosis factor, soluble form in PDB entry 3l9j, assembly 1, side view.
Tumor necrosis factor, soluble form in PDB entry 3l9j, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links