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THE KINASE DOMAIN OF HUMAN LYMPHOCYTE KINASE (LCK), ACTIVATED FORM (AUTO-PHOSPHORYLATED ON TYR394)

X-ray diffraction
1.7Å resolution
PDB entry 3lck coloured by chain, front view.
PDB entry 3lck coloured by chain, side view.
PDB entry 3lck coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Lck
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Multimeric state: monomeric
Accessible surface area: 13557.43 Å2
Buried surface area: 176.62 Å2
Dissociation area: 88.31 Å2
Dissociation energy (ΔGdiss): 14.96 kcal/mol
Dissociation entropy (TΔSdiss): 0.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138948
Monomeric assembly 1 of PDB entry 3lck coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 3lck coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 3lck coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 95%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 1
Symmetry : None
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Tyrosine-protein kinase Lck
Chain: A
Length: 271 amino acids
Theoretical weight: 31.43 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06239 (Residues: 231-501; Coverage: 53%)
Gene name: LCK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Tyrosine-protein kinase Lck in PDB entry 3lck, assembly 1, front view.
Tyrosine-protein kinase Lck in PDB entry 3lck, assembly 1, side view.
Tyrosine-protein kinase Lck in PDB entry 3lck, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P06239  
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