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SET7/9 Y245A in complex with TAF10-K189me2 peptide and AdoHcy

X-ray diffraction
1.7Å resolution
PDB entry 3m59 coloured by chain, front view.
PDB entry 3m59 coloured by chain, side view.
PDB entry 3m59 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcription initiation factor TFIID subunit 10 and Histone-lysine N-methyltransferase SETD7
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Multimeric state: hetero dimer
Accessible surface area: 11824.23 Å2
Buried surface area: 2908.29 Å2
Dissociation area: 795.39 Å2
Dissociation energy (ΔGdiss): 4.73 kcal/mol
Dissociation entropy (TΔSdiss): 7.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171459

Macromolecules

Histone-lysine N-methyltransferase SETD7
Chain: A
Length: 261 amino acids
Theoretical weight: 28.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WTS6 (Residues: 110-366; Coverage: 70%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Pfam:
InterPro:
CATH:
Histone-lysine N-methyltransferase SETD7 in PDB entry 3m59, assembly 1, front view.
Histone-lysine N-methyltransferase SETD7 in PDB entry 3m59, assembly 1, side view.
Histone-lysine N-methyltransferase SETD7 in PDB entry 3m59, assembly 1, top view.
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Transcription initiation factor TFIID subunit 10
Chain: B
Length: 11 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q12962 (Residues: 186-195; Coverage: 5%)
Gene names: TAF10, TAF2A, TAF2H, TAFII30
Transcription initiation factor TFIID subunit 10 in PDB entry 3m59, assembly 1, front view.
Transcription initiation factor TFIID subunit 10 in PDB entry 3m59, assembly 1, side view.
Transcription initiation factor TFIID subunit 10 in PDB entry 3m59, assembly 1, top view.
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