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HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues

X-ray diffraction
3.1Å resolution
PDB entry 3mh4 coloured by chain, front view.
PDB entry 3mh4 coloured by chain, side view.
PDB entry 3mh4 coloured by chain, top view.
Source organism: Escherichia coli K-12
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Periplasmic serine endoprotease DegP
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Multimeric state: homo hexamer
Accessible surface area: 82361.34 Å2
Buried surface area: 14872.23 Å2
Dissociation area: 2,725.9 Å2
Dissociation energy (ΔGdiss): 9.55 kcal/mol
Dissociation entropy (TΔSdiss): 15.93 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-142926
Assembly 2
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Assembly Name: Periplasmic serine endoprotease DegP
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Multimeric state: homo hexamer
Accessible surface area: 100650.23 Å2
Buried surface area: 20563.96 Å2
Dissociation area: 5,643.49 Å2
Dissociation energy (ΔGdiss): 38.32 kcal/mol
Dissociation entropy (TΔSdiss): 17.26 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-142926

Macromolecules

Periplasmic serine endoprotease DegP
Chains: A, B
Length: 456 amino acids
Theoretical weight: 47.93 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C0V0 (Residues: 27-474; Coverage: 100%)
Gene names: JW0157, b0161, degP, htrA, ptd
Pfam:
InterPro:
CATH:
Periplasmic serine endoprotease DegP in PDB entry 3mh4, assembly 1, front view.
Periplasmic serine endoprotease DegP in PDB entry 3mh4, assembly 1, side view.
Periplasmic serine endoprotease DegP in PDB entry 3mh4, assembly 1, top view.
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