Structure analysis

Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1)

X-ray diffraction
1.75Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 21467.64 Å2
Buried surface area: 6567.59 Å2
Dissociation area: 1,227 Å2
Dissociation energy (ΔGdiss): 24.05 kcal/mol
Dissociation entropy (TΔSdiss): 9.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116585

Macromolecules

PDBe-KB: UniProt Coverage View: Q9Y253  
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Name: DNA (5'-D(*CP*AP*(TTD)P*AP*TP*GP*AP*CP*GP*CP*T)-3')
Representative chains: T
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 11 nucleotides
Theoretical weight: 3.64 KDa
1111234567891011
 
510CA*ATGACGCT
Chains
Chain B (auth T)
Ligand binding sites
Interaction interfaces

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Name: DNA (5'-D(*CP*AP*GP*CP*GP*TP*CP*AP*T)-3')
Representative chains: P
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 9 nucleotides
Theoretical weight: 2.72 KDa
19123456789
 
246810CAGCGTCAT
Chains
RSRZ Outlier Chain C (auth P)
Chain C (auth P)
Ligand binding sites
Interaction interfaces

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