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Crystal structure of Co2+ HDAC8 complexed with M344

X-ray diffraction
3.2Å resolution
PDB entry 3mz3 coloured by chain, front view.
PDB entry 3mz3 coloured by chain, side view.
PDB entry 3mz3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone deacetylase 8
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Multimeric state: monomeric
Accessible surface area: 14099.17 Å2
Buried surface area: 1130.27 Å2
Dissociation area: 108.27 Å2
Dissociation energy (ΔGdiss): -0.08 kcal/mol
Dissociation entropy (TΔSdiss): 0.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189815
Assembly 2
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Assembly Name: Histone deacetylase 8
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Multimeric state: monomeric
Accessible surface area: 14231.74 Å2
Buried surface area: 919.63 Å2
Dissociation area: 110.21 Å2
Dissociation energy (ΔGdiss): -0.09 kcal/mol
Dissociation entropy (TΔSdiss): 0.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189815

Macromolecules

Histone deacetylase 8
Chains: A, B
Length: 389 amino acids
Theoretical weight: 43.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BY41 (Residues: 1-377; Coverage: 100%)
Gene names: CDA07, HDAC8, HDACL1
Pfam: Histone deacetylase domain
InterPro:
CATH: Histone deacetylase domain
Histone deacetylase 8 in PDB entry 3mz3, assembly 1, front view.
Histone deacetylase 8 in PDB entry 3mz3, assembly 1, side view.
Histone deacetylase 8 in PDB entry 3mz3, assembly 1, top view.
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