› › Structure analysis

A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor

X-ray diffraction
2.1Å resolution
PDB entry 3ncb coloured by chain, front view.
PDB entry 3ncb coloured by chain, side view.
PDB entry 3ncb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Prolactin receptor and Prolactin
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 20049.77 Å2
Buried surface area: 3061.27 Å2
Dissociation area: 1,196.68 Å2
Dissociation energy (ΔGdiss): 7.61 kcal/mol
Dissociation entropy (TΔSdiss): 12.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134124

Macromolecules

Prolactin
Chain: A
Length: 186 amino acids
Theoretical weight: 21.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01236 (Residues: 43-227; Coverage: 93%)
Gene name: PRL
Pfam: Somatotropin hormone family
InterPro:
CATH: Growth Hormone; Chain: A;
Prolactin in PDB entry 3ncb, assembly 1, front view.
Prolactin in PDB entry 3ncb, assembly 1, side view.
Prolactin in PDB entry 3ncb, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01236  
118620406080100120140160180
 
50100150MLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLERMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSAKIDNYLKLLKCRIIHNNNC
UniProt
P01236
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Variants
Molecule details ›

Search similar proteins

Prolactin receptor
Chain: B
Length: 210 amino acids
Theoretical weight: 24.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16471 (Residues: 25-234; Coverage: 35%)
Gene name: PRLR
Pfam: Erythropoietin receptor, ligand binding
InterPro:
CATH: Immunoglobulins
Prolactin receptor in PDB entry 3ncb, assembly 1, front view.
Prolactin receptor in PDB entry 3ncb, assembly 1, side view.
Prolactin receptor in PDB entry 3ncb, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P16471  
121020406080100120140160180200
 
50100150200MLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMND
UniProt
P16471
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Variants
Molecule details ›

Search similar proteins

Quick links