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Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of a rabies virus G protein

X-ray diffraction
1.43Å resolution
PDB entry 3nfk coloured by chain, front view.
PDB entry 3nfk coloured by chain, side view.
PDB entry 3nfk coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Glycoprotein and Tyrosine-protein phosphatase non-receptor type 4
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Multimeric state: hetero dimer
Accessible surface area: 6120.35 Å2
Buried surface area: 1355.9 Å2
Dissociation area: 564.9 Å2
Dissociation energy (ΔGdiss): 0.76 kcal/mol
Dissociation entropy (TΔSdiss): 7.62 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-527791
Assembly 2
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Assembly Name: Glycoprotein and Tyrosine-protein phosphatase non-receptor type 4
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Multimeric state: hetero dimer
Accessible surface area: 5769.5 Å2
Buried surface area: 768.6 Å2
Dissociation area: 384.3 Å2
Dissociation energy (ΔGdiss): 0.71 kcal/mol
Dissociation entropy (TΔSdiss): 5.7 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-527791
Assembly 3
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Assembly Name: Glycoprotein and Tyrosine-protein phosphatase non-receptor type 4
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Multimeric state: hetero tetramer
Accessible surface area: 11690.5 Å2
Buried surface area: 2324.58 Å2
Dissociation area: 664.93 Å2
Dissociation energy (ΔGdiss): -4.08 kcal/mol
Dissociation entropy (TΔSdiss): 17.92 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-527792

Macromolecules

Tyrosine-protein phosphatase non-receptor type 4
Chains: A, B
Length: 107 amino acids
Theoretical weight: 11.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29074 (Residues: 499-604; Coverage: 11%)
Gene name: PTPN4
Pfam: PDZ domain
InterPro:
CATH: Pdz3 Domain
Tyrosine-protein phosphatase non-receptor type 4 in PDB entry 3nfk, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 4 in PDB entry 3nfk, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 4 in PDB entry 3nfk, assembly 1, top view.
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Glycoprotein
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.48 KDa
Source organism: Lyssavirus rabies
Expression system: Not provided
UniProt:
  • Canonical: P03524 (Residues: 512-524; Coverage: 3%)
Gene name: G
Glycoprotein in PDB entry 3nfk, assembly 1, front view.
Glycoprotein in PDB entry 3nfk, assembly 1, side view.
Glycoprotein in PDB entry 3nfk, assembly 1, top view.
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