PDB 3nmd biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1

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Assembly Name: cGMP-dependent protein kinase 1

Multimeric state: homo dimer

Accessible surface area: 7682.54 Å²

Buried surface area: 2937.45 Å²

Dissociation area: 1,362.82 Å²

Dissociation energy (ΔG^diss): 24.76 kcal/mol

Dissociation entropy (TΔS^diss): 10.73 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-171845

Assembly 2

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Assembly Name: cGMP-dependent protein kinase 1

Multimeric state: homo dimer

Accessible surface area: 8040.17 Å²

Buried surface area: 4093.03 Å²

Dissociation area: 1,679.68 Å²

Dissociation energy (ΔG^diss): 14.05 kcal/mol

Dissociation entropy (TΔS^diss): 10.9 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-171845

Assembly 3 (preferred)

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Assembly Name: cGMP-dependent protein kinase 1

Multimeric state: homo dimer

Accessible surface area: 7393.41 Å²

Buried surface area: 3946.16 Å²

Dissociation area: 1,709.75 Å²

Dissociation energy (ΔG^diss): 18.71 kcal/mol

Dissociation entropy (TΔS^diss): 10.86 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-171845

Macromolecules

cGMP-dependent protein kinase 1

Chains: A, B, C, D, E
Length: 72 amino acids
Theoretical weight: 8.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:

Canonical: Q13976 (Residues: 4-47; Coverage: 6%)
Best match: Q13976-2 (Residues: 4-55)

Gene names: PRKG1, PRKG1B, PRKGR1A, PRKGR1B
Pfam: Coiled-coil N-terminus of cGMP-dependent protein kinase
InterPro: cGMP-dependent protein kinase, N-terminal coiled-coil domain
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces