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Crystal Structure of wild-type HIV-1 Protease in complex with kd20

X-ray diffraction
1.85Å resolution
PDB entry 3o9c coloured by chain, front view.
PDB entry 3o9c coloured by chain, side view.
PDB entry 3o9c coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Pol polyprotein
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Multimeric state: homo dimer
Accessible surface area: 9298.88 Å2
Buried surface area: 3985.95 Å2
Dissociation area: 1,992.97 Å2
Dissociation energy (ΔGdiss): 26.49 kcal/mol
Dissociation entropy (TΔSdiss): 11.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-187460

Macromolecules

Pol polyprotein
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.82 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q90K99 (Residues: 1-99; Coverage: 25%)
Gene name: pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Pol polyprotein in PDB entry 3o9c, assembly 1, front view.
Pol polyprotein in PDB entry 3o9c, assembly 1, side view.
Pol polyprotein in PDB entry 3o9c, assembly 1, top view.
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