Structure analysis

Crystal structure of InhA_T266E:NADH complex

X-ray diffraction
2Å resolution
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 32642.39 Å2
Buried surface area: 20818.52 Å2
Dissociation area: 4,241.05 Å2
Dissociation energy (ΔGdiss): 53.75 kcal/mol
Dissociation entropy (TΔSdiss): 15.2 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-161512

Macromolecules

Chain: A
Length: 269 amino acids
Theoretical weight: 28.58 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WGR1 (Residues: 1-269; Coverage: 100%)
Gene names: MTCY277.05, Rv1484, inhA
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain

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