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H-RasG12V with allosteric switch in the "off" state

X-ray diffraction
1.837Å resolution
PDB entry 3oiv coloured by chain, front view.
PDB entry 3oiv coloured by chain, side view.
PDB entry 3oiv coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GTPase HRas, N-terminally processed
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Multimeric state: monomeric
Accessible surface area: 7713.1 Å2
Buried surface area: 1735.54 Å2
Dissociation area: 100.51 Å2
Dissociation energy (ΔGdiss): -1.12 kcal/mol
Dissociation entropy (TΔSdiss): 2.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133956
Assembly 2
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Assembly Name: GTPase HRas, N-terminally processed
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Multimeric state: homo trimer
Accessible surface area: 20892.1 Å2
Buried surface area: 7250.2 Å2
Dissociation area: 1,115.11 Å2
Dissociation energy (ΔGdiss): 4.71 kcal/mol
Dissociation entropy (TΔSdiss): 23.07 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-133981

Macromolecules

GTPase HRas, N-terminally processed
Chain: A
Length: 166 amino acids
Theoretical weight: 18.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
GTPase HRas, N-terminally processed in PDB entry 3oiv, assembly 1, front view.
GTPase HRas, N-terminally processed in PDB entry 3oiv, assembly 1, side view.
GTPase HRas, N-terminally processed in PDB entry 3oiv, assembly 1, top view.
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