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Crystal structure of estrogen receptor beta ligand binding domain

X-ray diffraction
2.2Å resolution
PDB entry 3ols coloured by chain, front view.
PDB entry 3ols coloured by chain, side view.
PDB entry 3ols coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nuclear receptor coactivator 1 and Estrogen receptor beta
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Multimeric state: hetero dimer
Accessible surface area: 11632.82 Å2
Buried surface area: 1726.93 Å2
Dissociation area: 549.25 Å2
Dissociation energy (ΔGdiss): 5.01 kcal/mol
Dissociation entropy (TΔSdiss): 7.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172397
Assembly 2
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Assembly Name: Nuclear receptor coactivator 1 and Estrogen receptor beta
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Multimeric state: hetero dimer
Accessible surface area: 11614.28 Å2
Buried surface area: 1633.31 Å2
Dissociation area: 502.39 Å2
Dissociation energy (ΔGdiss): 4.08 kcal/mol
Dissociation entropy (TΔSdiss): 7.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172397
Assembly 3
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Assembly Name: Nuclear receptor coactivator 1 and Estrogen receptor beta
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Multimeric state: hetero tetramer
Accessible surface area: 20400.08 Å2
Buried surface area: 6207.26 Å2
Dissociation area: 1,423.51 Å2
Dissociation energy (ΔGdiss): 6.41 kcal/mol
Dissociation entropy (TΔSdiss): 13.26 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172402

Macromolecules

Estrogen receptor beta
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92731 (Residues: 261-500; Coverage: 45%)
Gene names: ESR2, ESTRB, NR3A2
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Estrogen receptor beta in PDB entry 3ols, assembly 1, front view.
Estrogen receptor beta in PDB entry 3ols, assembly 1, side view.
Estrogen receptor beta in PDB entry 3ols, assembly 1, top view.
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Nuclear receptor coactivator 1
Chains: C, D
Length: 19 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 683-701; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1
InterPro: Nuclear receptor coactivator, receptor-binding domain
Nuclear receptor coactivator 1 in PDB entry 3ols, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 3ols, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 3ols, assembly 1, top view.
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