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MDR769 HIV-1 protease complexed with PR/RT hepta-peptide

X-ray diffraction
1.7Å resolution
PDB entry 3ou3 coloured by chain, front view.
PDB entry 3ou3 coloured by chain, side view.
PDB entry 3ou3 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nucleocapsid protein p7
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Multimeric state: hetero trimer
Accessible surface area: 10470.34 Å2
Buried surface area: 4347.3 Å2
Dissociation area: 692.13 Å2
Dissociation energy (ΔGdiss): 1.48 kcal/mol
Dissociation entropy (TΔSdiss): 6.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-543490

Macromolecules

Protease
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.77 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P35963 (Residues: 489-587; Coverage: 7%)
Gene name: gag-pol
Pfam: Retroviral aspartyl protease
InterPro:
CATH: Acid Proteases
Protease in PDB entry 3ou3, assembly 1, front view.
Protease in PDB entry 3ou3, assembly 1, side view.
Protease in PDB entry 3ou3, assembly 1, top view.
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Protease
Chain: C
Length: 7 amino acids
Theoretical weight: 787 Da
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P35963 (Residues: 585-591; Coverage: 1%)
Gene name: gag-pol
Protease in PDB entry 3ou3, assembly 1, front view.
Protease in PDB entry 3ou3, assembly 1, side view.
Protease in PDB entry 3ou3, assembly 1, top view.
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