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Crystal structure of the mutant R160A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

X-ray diffraction
1.396Å resolution
PDB entry 3p61 coloured by chain, front view.
PDB entry 3p61 coloured by chain, side view.
PDB entry 3p61 coloured by chain, top view.
Source organism: Methanothermobacter thermautotrophicus str. Delta H
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Orotidine 5'-phosphate decarboxylase
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Multimeric state: homo dimer
Accessible surface area: 15739.36 Å2
Buried surface area: 4855.62 Å2
Dissociation area: 1,836.29 Å2
Dissociation energy (ΔGdiss): 32.23 kcal/mol
Dissociation entropy (TΔSdiss): 12.98 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127822

Macromolecules

Orotidine 5'-phosphate decarboxylase
Chains: A, B
Length: 228 amino acids
Theoretical weight: 24.8 KDa
Source organism: Methanothermobacter thermautotrophicus str. Delta H
Expression system: Escherichia coli
UniProt:
  • Canonical: O26232 (Residues: 1-228; Coverage: 100%)
Gene names: MTH_129, pyrF
Pfam: Orotidine 5'-phosphate decarboxylase / HUMPS family
InterPro:
CATH: Aldolase class I
Orotidine 5'-phosphate decarboxylase in PDB entry 3p61, assembly 1, front view.
Orotidine 5'-phosphate decarboxylase in PDB entry 3p61, assembly 1, side view.
Orotidine 5'-phosphate decarboxylase in PDB entry 3p61, assembly 1, top view.
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