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Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981

Source organisms:
Biochemical function: G protein-coupled receptor activity
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF01094
Domain description: Receptor family ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 3qem contains 2 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 1. Showing 1 copy in chain A.
The deposited structure of PDB entry 3qem contains 2 copies of Pfam domain PF01094 (Receptor family ligand binding region) in Glutamate receptor ionotropic, NMDA 2B. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001828
Domain description: Receptor, ligand binding region
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR028082
Domain description: Periplasmic binding protein-like I
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
IPR015683
Domain description: Ionotropic glutamate receptor
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 2B
IPR000068
Domain description: GPCR, family 3, extracellular calcium-sensing receptor-related
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1

Structure domain

CATH CATH domain
3.40.50.2300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Glutamate receptor ionotropic, NMDA 1
  2. Glutamate receptor ionotropic, NMDA 2B
The deposited structure of PDB entry 3qem contains 4 copies of CATH domain 3.40.50.2300 (Rossmann fold) in Glutamate receptor ionotropic, NMDA 1. Showing 2 copies in chain A.
The deposited structure of PDB entry 3qem contains 4 copies of CATH domain 3.40.50.2300 (Rossmann fold) in Glutamate receptor ionotropic, NMDA 2B. Showing 2 copies in chain B.

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