Structure analysis

Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981

X-ray diffraction
3.003Å resolution
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 29112.58 Å2
Buried surface area: 4289.41 Å2
Dissociation area: 1,341.36 Å2
Dissociation energy (ΔGdiss): 9.13 kcal/mol
Dissociation entropy (TΔSdiss): 13.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-103591
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 27912.6 Å2
Buried surface area: 2692.52 Å2
Dissociation area: 1,099.68 Å2
Dissociation energy (ΔGdiss): 4.39 kcal/mol
Dissociation entropy (TΔSdiss): 13.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-103591

Macromolecules

Chains: A, C
Length: 383 amino acids
Theoretical weight: 42.93 KDa
Source organism: Xenopus laevis
Expression system: Trichoplusia ni
UniProt: Gene name: grin1
Pfam: Receptor family ligand binding region
InterPro:
CATH: Rossmann fold

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Chains: B, D
Length: 364 amino acids
Theoretical weight: 41.37 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00960 (Residues: 31-394; Coverage: 25%)
Gene name: Grin2b
Pfam: Receptor family ligand binding region
InterPro:
CATH: Rossmann fold

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