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Human Class I MHC HLA-A2 in complex with Mart-1(27-35) nonameric peptide

X-ray diffraction
1.68Å resolution
PDB entry 3qfd coloured by chain, front view.
PDB entry 3qfd coloured by chain, side view.
PDB entry 3qfd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 18836.12 Å2
Buried surface area: 5245.92 Å2
Dissociation area: 747.65 Å2
Dissociation energy (ΔGdiss): 8.19 kcal/mol
Dissociation entropy (TΔSdiss): 6.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137805
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18825.55 Å2
Buried surface area: 4706.35 Å2
Dissociation area: 710.4 Å2
Dissociation energy (ΔGdiss): 7.9 kcal/mol
Dissociation entropy (TΔSdiss): 6.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137805

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 3qfd, assembly 2, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 3qfd, assembly 2, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 3qfd, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P04439  
127520406080100120140160180200220240260
 
100200
UniProt
P04439
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 3qfd, assembly 2, front view.
Beta-2-microglobulin in PDB entry 3qfd, assembly 2, side view.
Beta-2-microglobulin in PDB entry 3qfd, assembly 2, top view.
PDBe-KB: UniProt Coverage View: P61769  
1100102030405060708090100
 
50100MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt
P61769
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
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Melanoma antigen recognized by T-cells 1
Chains: C, F
Length: 9 amino acids
Theoretical weight: 814 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16655 (Residues: 27-35; Coverage: 8%)
Gene names: MART1, MLANA
Melanoma antigen recognized by T-cells 1 in PDB entry 3qfd, assembly 2, front view.
Melanoma antigen recognized by T-cells 1 in PDB entry 3qfd, assembly 2, side view.
Melanoma antigen recognized by T-cells 1 in PDB entry 3qfd, assembly 2, top view.
PDBe-KB: UniProt Coverage View: Q16655  
19123456789
 
246810AAGIGILTV
UniProt
Q16655
Chains
Flexibility predictions
Interaction interfaces
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