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Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate

X-ray diffraction
2.2Å resolution
PDB entry 3qkq coloured by chain, front view.
PDB entry 3qkq coloured by chain, side view.
PDB entry 3qkq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1
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Multimeric state: monomeric
Accessible surface area: 13368.26 Å2
Buried surface area: 1081.29 Å2
Dissociation area: 58.32 Å2
Dissociation energy (ΔGdiss): -0.94 kcal/mol
Dissociation entropy (TΔSdiss): 1.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148259
Monomeric assembly 1 of PDB entry 3qkq coloured by chemically distinct molecules, front view.
Monomeric assembly 1 of PDB entry 3qkq coloured by chemically distinct molecules, side view.
Monomeric assembly 1 of PDB entry 3qkq coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 95%
No. subunits : 1
Symmetry : None
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3DComplex & QSbio predictionx
No. subunits : 1
Symmetry : None
Evidence : This biological assembly agrees with the prediction of both PISA & EPPIC

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chain: A
Length: 321 amino acids
Theoretical weight: 37.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18031 (Residues: 1-321; Coverage: 74%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 3qkq, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 3qkq, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 3qkq, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P18031  
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