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Structure of a cytokine ligand-receptor complex

X-ray diffraction
2.55Å resolution
PDB entry 3qt2 coloured by chain, front view.
PDB entry 3qt2 coloured by chain, side view.
PDB entry 3qt2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-5 complex and Interleukin-5 receptor subunit alpha
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Multimeric state: hetero trimer
Accessible surface area: 27358.14 Å2
Buried surface area: 10082.17 Å2
Dissociation area: 1,238.29 Å2
Dissociation energy (ΔGdiss): -2.44 kcal/mol
Dissociation entropy (TΔSdiss): 12.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138518
Assembly 2
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Assembly Name: Interleukin-5 complex and Interleukin-5 receptor subunit alpha
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Multimeric state: hetero trimer
Accessible surface area: 26584.6 Å2
Buried surface area: 10231.6 Å2
Dissociation area: 1,313.01 Å2
Dissociation energy (ΔGdiss): 1.43 kcal/mol
Dissociation entropy (TΔSdiss): 12.97 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138518

Macromolecules

Interleukin-5 receptor subunit alpha
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01344 (Residues: 20-332; Coverage: 78%)
  • Best match: Q01344-2 (Residues: 20-335)
Gene names: IL5R, IL5RA
Pfam: Interleukin-6 receptor alpha chain, binding
InterPro:
CATH: Immunoglobulins
Interleukin-5 receptor subunit alpha in PDB entry 3qt2, assembly 1, front view.
Interleukin-5 receptor subunit alpha in PDB entry 3qt2, assembly 1, side view.
Interleukin-5 receptor subunit alpha in PDB entry 3qt2, assembly 1, top view.
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Interleukin-5
Chains: C, D, E, F
Length: 117 amino acids
Theoretical weight: 13.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05113 (Residues: 19-134; Coverage: 100%)
Gene name: IL5
Pfam: Interleukin 5
InterPro:
CATH: Growth Hormone; Chain: A;
Interleukin-5 in PDB entry 3qt2, assembly 1, front view.
Interleukin-5 in PDB entry 3qt2, assembly 1, side view.
Interleukin-5 in PDB entry 3qt2, assembly 1, top view.
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