Structure analysis

Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgATP

X-ray diffraction
1.87Å resolution
Source organism: Streptomyces wedmorensis
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 20094.3 Å2
Buried surface area: 5042.75 Å2
Dissociation area: 1,282.15 Å2
Dissociation energy (ΔGdiss): 10.55 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-176325

Macromolecules

Chain: A
Length: 286 amino acids
Theoretical weight: 30.88 KDa
Source organism: Streptomyces wedmorensis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q56187 (Residues: 1-266; Coverage: 100%)
Gene name: fomA
Pfam: Amino acid kinase family
InterPro:
CATH: Acetylglutamate kinase-like

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