› › Structure analysis

I. Novel HCV NS5B Polymerase Inhibitors: Discovery of Indole 2- Carboxylic Acids with C3-Heterocycles

X-ray diffraction
2.5Å resolution
PDB entry 3skh coloured by chain, front view.
PDB entry 3skh coloured by chain, side view.
PDB entry 3skh coloured by chain, top view.
Source organism: Hepatitis C virus isolate HC-J4
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: RNA-directed RNA polymerase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 23462.2 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131655
Assembly 2
Download    3D Visualisation
Assembly Name: RNA-directed RNA polymerase
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 23423.99 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131655

Macromolecules

RNA-directed RNA polymerase
Chains: A, B
Length: 576 amino acids
Theoretical weight: 64.19 KDa
Source organism: Hepatitis C virus isolate HC-J4
Expression system: Escherichia coli
UniProt:
  • Canonical: O92972 (Residues: 2420-2989; Coverage: 19%)
Pfam: Viral RNA dependent RNA polymerase
InterPro:
RNA-directed RNA polymerase in PDB entry 3skh, assembly 1, front view.
RNA-directed RNA polymerase in PDB entry 3skh, assembly 1, side view.
RNA-directed RNA polymerase in PDB entry 3skh, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links