3sko › Citations

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule.

Gras S, Wilmann PG, Chen Z, Halim H, Liu YC, Kjer-Nielsen L, Purcell AW, Burrows SR, McCluskey J, Rossjohn J
J Immunol 188 311-21 (2012)
Related entries: 3sjv, 3skm, 3skn

Cited: 40 times
EuropePMC logo PMID: 22140258

Abstract

EBV is a ubiquitous and persistent human pathogen, kept in check by the cytotoxic T cell response. In this study, we investigated how three TCRs, which differ in their T cell immunodominance hierarchies and gene usage, interact with the same EBV determinant (FLRGRAYGL), bound to the same Ag-presenting molecule, HLA-B8. We found that the three TCRs exhibit differing fine specificities for the viral Ag. Further, via structural and biophysical approaches, we demonstrated that the viral Ag provides the greatest energetic contribution to the TCR-peptide-HLA interaction, while focusing on a few adjacent HLA-based interactions to further tune fine-specificity requirements. Thus, the TCR engages the peptide-HLA with the viral Ag as the main glue, such that neighboring TCR-MHC interactions are recruited as a supportive adhesive. Collectively, we provide a portrait of how the host's adaptive immune response differentially engages a common viral Ag.

Articles - 3sko mentioned but not cited (2)

  1. Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing. Li L, Peng X, Batliwala M, Bouvier M. Nat Commun 14 5020 (2023)
  2. research-article Unusual crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing in antigen presentation. Li L, Peng X, Batliwala M, Bouvier M. Res Sq rs.3.rs-2500847 (2023)


Reviews citing this publication (11)

  1. T cell antigen receptor recognition of antigen-presenting molecules. Rossjohn J, Gras S, Miles JJ, Turner SJ, Godfrey DI, McCluskey J. Annu Rev Immunol 33 169-200 (2015)
  2. Understanding the drivers of MHC restriction of T cell receptors. La Gruta NL, Gras S, Daley SR, Thomas PG, Rossjohn J. Nat Rev Immunol 18 467-478 (2018)
  3. Using T Cell Receptor Repertoires to Understand the Principles of Adaptive Immune Recognition. Bradley P, Thomas PG. Annu Rev Immunol 37 547-570 (2019)
  4. TCR Recognition of Peptide-MHC-I: Rule Makers and Breakers. Szeto C, Lobos CA, Nguyen AT, Gras S. Int J Mol Sci 22 E68 (2020)
  5. A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned. Gras S, Burrows SR, Turner SJ, Sewell AK, McCluskey J, Rossjohn J. Immunol Rev 250 61-81 (2012)
  6. Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes. Singh NK, Riley TP, Baker SCB, Borrman T, Weng Z, Baker BM. J Immunol 199 2203-2213 (2017)
  7. Understanding the complexity and malleability of T-cell recognition. Miles JJ, McCluskey J, Rossjohn J, Gras S. Immunol Cell Biol 93 433-441 (2015)
  8. Mechanisms and Consequences of Antigen Presentation by CD1. Van Kaer L, Wu L, Joyce S. Trends Immunol 37 738-754 (2016)
  9. Transplantation tolerance and its outcome during infections and inflammation. Chong AS, Alegre ML. Immunol Rev 258 80-101 (2014)
  10. The versatility of the αβ T-cell antigen receptor. Bhati M, Cole DK, McCluskey J, Sewell AK, Rossjohn J. Protein Sci 23 260-272 (2014)
  11. Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules? Eckle SB, Turner SJ, Rossjohn J, McCluskey J. Curr Opin Immunol 25 653-659 (2013)

Articles citing this publication (27)



Quick links