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Crystal structure of the HLA-B8-A66-FLR, mutant A66 of the HLA B8

X-ray diffraction
1.6Å resolution
PDB entry 3sko coloured by chain, front view.
PDB entry 3sko coloured by chain, side view.
PDB entry 3sko coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19222.01 Å2
Buried surface area: 4718.22 Å2
Dissociation area: 1,321.94 Å2
Dissociation energy (ΔGdiss): 8.09 kcal/mol
Dissociation entropy (TΔSdiss): 12.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135249

Macromolecules

HLA class I histocompatibility antigen, B alpha chain
Chain: A
Length: 277 amino acids
Theoretical weight: 31.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 25-301; Coverage: 82%)
Gene names: HLA-B, HLAB
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, B alpha chain in PDB entry 3sko, assembly 1, front view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 3sko, assembly 1, side view.
HLA class I histocompatibility antigen, B alpha chain in PDB entry 3sko, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P01889  
127720406080100120140160180200220240260
 
100200GSHSMRYFDTAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQAFKTNTQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHNQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARVAEQDRAYLEGTCVEWLRRYLENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPS
UniProt
P01889
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 3sko, assembly 1, front view.
Beta-2-microglobulin in PDB entry 3sko, assembly 1, side view.
Beta-2-microglobulin in PDB entry 3sko, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P61769  
1100102030405060708090100
 
50100MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
UniProt
P61769
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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Epstein-Barr nuclear antigen 3
Chain: C
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: human gammaherpesvirus 4
Expression system: Not provided
UniProt:
  • Canonical: Q3KST2 (Residues: 325-333; Coverage: 1%)
Gene names: BLRF3-BERF1, EBNA3
Epstein-Barr nuclear antigen 3 in PDB entry 3sko, assembly 1, front view.
Epstein-Barr nuclear antigen 3 in PDB entry 3sko, assembly 1, side view.
Epstein-Barr nuclear antigen 3 in PDB entry 3sko, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q3KST2  
19123456789
 
246810FLRGRAYGL
UniProt
Q3KST2
Chains
Flexibility predictions
Interaction interfaces
Molecule details ›

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