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Structural basis of the improvement of ChrR - a multi-purpose enzyme

Source organism: Escherichia coli K-12
Biochemical function: NADH:ubiquinone reductase (non-electrogenic) activity
Biological process: protein homotetramerization
Cellular component: cytosol

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EC 1.6.5.2: NAD(P)H dehydrogenase (quinone)

Reaction catalysed:
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone
Systematic name:
NAD(P)H:quinone oxidoreductase
Alternative Name(s):
  • Azoreductase
  • DT-diaphorase
  • Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone)
  • Diaphorase
  • Flavoprotein NAD(P)H-quinone reductase
  • Menadione oxidoreductase
  • Menadione reductase
  • NAD(P)H dehydrogenase
  • NAD(P)H menadione reductase
  • NAD(P)H(2) dehydrogenase (quinone)
  • NAD(P)H-quinone dehydrogenase
  • NAD(P)H-quinone oxidoreductase
  • NAD(P)H: menadione oxidoreductase
  • NAD(P)H:(quinone-acceptor)oxidoreductase
  • NADH-menadione reductase
  • NQO1
  • Naphthoquinone reductase
  • Phylloquinone reductase
  • QR1
  • Quinone reductase
  • Reduced NAD(P)H dehydrogenase
  • Reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase
  • Viologen accepting pyridine nucleotide oxidoreductase
  • Vitamin K reductase
  • Vitamin-K reductase
  • p-benzoquinone reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03358
Domain description: NADPH-dependent FMN reductase
Occurring in:
  1. Quinone reductase
The deposited structure of PDB entry 3svl contains 2 copies of Pfam domain PF03358 (NADPH-dependent FMN reductase) in Quinone reductase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR029039
Domain description: Flavoprotein-like superfamily
Occurring in:
  1. Quinone reductase
IPR005025
Domain description: NADPH-dependent FMN reductase-like domain
Occurring in:
  1. Quinone reductase

Structure domain

CATH CATH domain
3.40.50.360
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Quinone reductase
The deposited structure of PDB entry 3svl contains 2 copies of CATH domain 3.40.50.360 (Rossmann fold) in Quinone reductase. Showing 1 copy in chain B.

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