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The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2 subtype)

X-ray diffraction
3.2Å resolution
PDB entry 3tls coloured by chain, front view.
PDB entry 3tls coloured by chain, side view.
PDB entry 3tls coloured by chain, top view.
Source organism: Gloeobacter violaceus
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proton-gated ion channel
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Multimeric state: homo pentamer
Accessible surface area: 62723.99 Å2
Buried surface area: 23663.48 Å2
Dissociation area: 11,368.79 Å2
Dissociation energy (ΔGdiss): 129.29 kcal/mol
Dissociation entropy (TΔSdiss): 60.41 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-181806
Homo pentameric assembly 1 of PDB entry 3tls coloured by chemically distinct molecules, front view.
Homo pentameric assembly 1 of PDB entry 3tls coloured by chemically distinct molecules, side view.
Homo pentameric assembly 1 of PDB entry 3tls coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 5
Symmetry : C5
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3DComplex & QSbio predictionx
No. subunits : 5
Symmetry : C5
Evidence : quaternary structure geometry is similar to that of 3rqw_1 (22% id)

Macromolecules

Proton-gated ion channel
Chains: A, B, C, D, E
Length: 321 amino acids
Theoretical weight: 36.55 KDa
Source organism: Gloeobacter violaceus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7NDN8 (Residues: 44-359; Coverage: 100%)
Gene names: glr4197, glvI
Pfam: Neurotransmitter-gated ion-channel ligand binding domain
InterPro:
CATH:
Proton-gated ion channel in PDB entry 3tls, assembly 1, front view.
Proton-gated ion channel in PDB entry 3tls, assembly 1, side view.
Proton-gated ion channel in PDB entry 3tls, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q7NDN8  
132150100150200250300
 
100200300
UniProt
Q7NDN8
Chains
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Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
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